Two sample MR report
HLA-DRB5_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 27 | 0.0949351 | 0.0906136 | 0.3048047 |
| Weighted median | 27 | 0.0923430 | 0.0226009 | 0.0000439 |
| Inverse variance weighted | 27 | 0.0756131 | 0.0174499 | 0.0000147 |
| Simple mode | 27 | 0.1033042 | 0.0448491 | 0.0295094 |
| Weighted mode | 27 | 0.1006946 | 0.0406426 | 0.0200482 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 16.37676 | 25 | 0.9031461 |
| Inverse variance weighted | 16.42398 | 26 | 0.9254554 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0077709 | 0.0357609 | 0.8297365 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003681 | 0 | TRUE | 0.0689523 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
